Starring Christina Applegate (Friends, Married With Children), this brand new US comedy series features Samantha Newly (Applegate), a corporate executive and hit-and-run victim who wakes up after being in a coma for eight days, only to find she has amnesia. With no memory of the past, she must rediscover everything about her life and herself by looking for clues from her past.

Slowly but surely little parts of her start to emerge - to the delight of some and to the shock of others. Vain, selfish, lacking conscience or heart, she had far more enemies than friends. So when Samantha learns that her ‘accident’ was actually an attempted murder, she is not surprised. As our heroine begins the long, comic process of starting over, she fears that the ‘old Sam’ might return or worse, her would-be killer will try again. Samantha tries to remake herself through good, positive choices - even though the bad ones are so much easier (and way more fun). Samantha Who? also stars Jennifer Esposito, Barry Watson Jean Smart Kevin Dunn, Melissa McCarthy and Tim Russ.

Samantha Who? Launches Tomorrow night on E4