Leonard and Sheldon are two very brainy best friends who can you tell you anything you want to know about quantum physics, but know next to nothing about the real world, especially women.

All this begins to change when a free-spirited beauty named Penny (Kaley Cuoco - Charmed ) moves in next door. Sheldon and Leonard go to Penny’s apartment to drop off a package. But Sheldon can’t believe how messy her apartment is and, later that night, when Leonard is sleeping, sneaks round to clean and organise it. But, when she wakes to find what Sheldon has done, Penny’s not pleased…

Thursday 21 February 2008, Channel 4 10PM

Brand new US comedy. Two brainy best friends, Leonard and Sheldon could tell you anything you want to know about quantum physics, but when it comes to dealing with everyday life here on Earth, they’re lost in the cosmos.

Leonard and Sheldon are brilliant physicists, the kind of “beautiful minds” that understand how the universe works. But none of that genius helps them interact with people, especially women. All this begins to change in this new sitcom when a free-spirited beauty named Penny moves in next door.

Thursday 14 February 2008
10:00pm, Channel 4